Having worked with and in multiple technology startups in all these areas, I've seen first-hand that the differences are stark. Successful tech startups in "The Alley" tend toward sales and business heaviness. While this drives revenue and validates opportunity early (which is excellent) serious issues arise at scale when sound, experienced technical leadership and decision making isn't proactively integrated into the culture and DNA. Great ideas and opportunities without technical execution are doomed to failure as reality strays more and more from the promises of sales and marketing. Worse yet, the repeating pattern of this misstep creates a false perception that the talent for technical execution and innovation is not to be found in the area at all. In this scenario, perception becomes self-fulfilling prophecy driven by poor selection and fostering of talent at the highest levels.
On the other side of the coin "The Alley" is brimming with brilliant and experienced technologists doing amazing things with what they know about both their trade and industry. Unfortunately, very few of them are looking at the alignment of that work with the business opportunity that could elevate them to innovation greatness. More than that, the syndrome above promises them little hope of reward or recognition for bridging this gap or for partnering with those with the business acumen they so desperately need. The "culture of misalignment" strikes again here, discouraging or preventing technologist from working at this balance in themselves and their organizations. The syndrome's final outcome is an "us and them" mentality that promotes technical mediocrity, which tends to be predictable and tactical - focused on low risk, low value "wins" and distance from largely orphaned, higher-risk, more innovative efforts that may or may not be overly ambitious.
Enterprise Architecture professionals and practices have been pushing this alignment top down in large organizations for decades and "The Alley" is a veritable gold mine of those professionals. That being said, especially in a young tech company, the continued ability to execute and get your hands dirty at the leadership level is still critical. In fact, Silicon Valley companies like Google and Amazon still look for that kind of background from their leaders and regularly recruit and relocate from here. Finding the right technical leaders, empowering them, and making sure that the whole organization is built to reward strategic innovation, measured risk taking, and technical excellence that maps to the bottom line and competitive advantage is the most critical commitment a company can make.
The commitment to business and technical alignment is the key missing piece in the alley's start-up culture. Where there has been success here, you'll see exceptions to the rule and people willing to truly push the envelope. Building a culture that evangelizes, fosters, and rewards this re-alignment could fundamentally transform the innovation landscape in the area and set the tone to make the alley a hub of new kinds of companies built around the unique value propositions available.